This page provides a history of updates to the CMF-CW frontend, backend, and database, which are versioned separately.
Frontend Version 1.0 — June 21, 2026. Initial public release of the CMF-CW frontend.
Backend Version 1.0 — June 21, 2026. Initial public release of the CMF-CW backend.
Database Version 1.0 — June 21, 2026. Initial public release of the CMF-CW database.
Frontend Version 1.1 — June 29, 2026. Resolved an issue that caused the chemical weapons control lists and database-related parameters to load slowly.
Frontend Version 1.2 — June 29, 2026. Improved error handling when using a VPN.
Backend Version 1.1 — July 2, 2026. Fixed an issue whereby PubChem CIDs were not retrieved for chemicals containing triple bonds. The issue arose because triple bonds are encoded in SMILES strings using the # character, which is not transmitted reliably when included in a URL path. The relevant function was modified to send the SMILES string to PubChem as a parameter rather than incorporating it into the URL path.
Backend Version 1.2 — July 2, 2026. Updated the URL for the OPSIN service following its migration from the University of Cambridge website to the European Bioinformatics Institute website.
Backend Version 1.3 — July 10, 2026. Modified the backend to retrieve PubChem CIDs for all variants only when the verbose option is selected. This change significantly speeds up searches by avoiding the retrieval of information that is not displayed.
Frontend Version 1.3 — July 10, 2026. Added a Frequently Asked Questions page to the CMF-CW website.
Backend Version 1.4 — July 14, 2026. Fixed an issue that caused CWC Schedule 2 entry 2B4 to incorrectly match certain branched alkyl groups other than isopropyl.
Frontend Version 1.4 — July 14, 2026. Added a Version History page to the CMF-CW website.
Frontend Version 1.5 — July 20, 2026. Added PubChem-powered autocomplete suggestions to the search-term input field.
Frontend Version 1.6 — July 23, 2026. Expanded autocomplete by integrating Wikidata alongside PubChem and combining duplicate-free suggestions from both services.
Backend Version 1.5 — July 23, 2026. Fixed an issue affecting the recognition of amidines during the variant-generation process.
Backend Version 1.6 — July 23, 2026. Consolidated PubChem requests within each search into a single reusable connection session. This change improves performance without affecting the information retrieved.
Backend Version 1.7 — July 23, 2026. Added a note when the graphical display is limited to the first 100 structures, explaining that additional generated variants can be listed in the textual report by selecting the verbose option.
Backend Version 1.8 — July 23, 2026. Improved the performance of molecular-variant generation by avoiding redundant tautomer-enumeration steps. Also implemented additional minor performance improvements by optimizing the creation and reuse of certain RDKit objects and molecular patterns. These changes reduce processing time without affecting the generated tautomers and other molecular variants. Additionally, updated the Google Cloud deployment parameters to improve backend performance.
Backend Version 1.9 — September 10, 2026. Updated the displayed name of the Australia Group list to “Australia Group CW Precursors.”
Backend Version 1.10 — September 10, 2026. Improved the presentation of metadata-only matches. When a search term matches an entry through the metadata search but does not produce a structural match, the results now display the original text input rather than the structure obtained from text-to-structure conversion. Structure-related information, including PubChem CID, text-to-SMILES service, canonical SMILES, generated variants, and messages concerning the absence of structural matches, is also omitted in these cases. These changes help distinguish metadata matches from structural matches and avoid implying that a resolved structure is responsible for a metadata-only hit.
Learn More and Launch CMF-CW
To explore CMF-CW in more detail, visit the following pages:
- About CMF-CW – Background on the project
- Database of CW-Control Lists – The database currently implemented in CMF-CW
- How to Use CMF-CW – A step-by-step user guide
- How CMF-CW Works – Overview of the technical methodology and system design
- Frequently Asked Questions – Answers to common questions about CMF-CW
When you are ready, launch the CMF-CW screening tool.